Home » Courses » Thyroid » Benign conditions » Χρόνια λεμφοκυτταρική θυρεοειδίτιδα Hashimoto

Thyroid

Χρόνια λεμφοκυτταρική θυρεοειδίτιδα Hashimoto

???? ????? ??? ????????? ?????  ???? ????? ?? ????????? ?????????????? ??? ??????? ?????????? ???????? ?? ???????? ??????, ??? ??????? ????? ?? ??????? ??????????? ???????????? ?????. ?????????????? ?????????????? ?? ?????? ????????, ???? ?????????? ???? ??? ???????????? ????????????? ????????? ??? ???????? ??? ????????? ??? TSH.

? ?????? ??????? ???? ???????? ???????, ????? ????, ?? ? ????? ???????? ???????. ??????? ???????? ?????? ?? ????? ???? ???? ???????????????? ? ??????????????, ???? ???????? ?? ???????????? ???????? ???????????????.

????????????? ??????????? ??????????????

  • ?????? ????????? ?????????????
  • ????????? tingible-body
  • ???????????????????? ?????????
  • ??????? Hürtle

? ??????????? ????? ??????? ?????????????, ?????? ??????????? ??? ???????????? (????? ????????????, ????????????? ??? ?????????????), ?? ????? ?????? ?? ?????????? ??????? ??? ?????????? ???????, ????? ??? ???????????????. ?? ???????????????????? ?????????, ??? ?? tingible-body ????????? ????? ?????? ???????. ???????????? ?????? ???????????? ???????? ?????????????, ??????? ?? ???????????? ??????????, ??? ?????????????  ?????????? (Hürtle cell ??????????): ????? ??????, ??????????, ???????? ????????????? ??? ?????? ??????.  ?????????? ?????????????? ?????? ?????? ?? ????????. ?? ?????????? ????? ???? ? ????????.

? ????????????? ???????? ????? ??????? ??????, ???? ?????????? ??????????? ?? ??? ???????? ??? ??????????????? ???? ???.

????????? ????????

  • ??-Hodgkin ???????
  • Hürtle cell?????????

? ???????? ?????????? ????? ???????? ????? ???????? ?? ????????????? Hashimoto. ?? ??????? ??????? ??????????? ??? ???? ?????????? ???????? ?????? ?????????? ????????. ?? Hürtle cell ??????????? ?????? ?? ?????????????????? ??? ???????????? Hürtle cell ??????, ?? ????? ?????? ?? ???????????? ?? ????????????? Hashimoto. ?? ??????? ??? ?? ????????? ????? ?????? ??????? ??? ????? ????????? ?????? ??? ??? ???? ?????????????.

A low power view of Hashimoto's thyroiditis. Very cellular background with numerous lymphocytes and a few follicular groups.
Histiocytes surrounded by lymphocytes. A group of histiocytes in a background of a polymorphic lymphoid population and plasmacells.
A follicle surrounded by a polymorphic lymphoid infiltration. A follicle containing colloid surrounded by a polymorphic lymphoid population. Note the streaks of nuclear material from the more fragile lymphocytes. When present within better preserved epithelial cells this is suggestive of intraepithelial lymphocytic infiltration.

Follicular cells surrounded by lymphocytes.

A group of epithelial cells surrounded and partially infiltrated by lymphocytes. Note the variability of nuclear size and granular chromatin. Often individual cells may cause problem at high power. When clear cut nuclear pseudoinclusions are seen the suspicion of a papillary carcinoma in a background of chronic thyroiditis should be raised.

A follicle infiltrated by lymphocytes.

A group of slightly crowded epithelial cells in a follicular arrangement, infiltrated by lymphocytes. Note the nuclear streaking.

Lymphocytes, plasmacells admixed with poorly preserved thyroid epithelial cells. A polymorphic population of lymphocytes and plasmacells admixed (lower left side) with epithelial cells which exhibit a denser cytoplasm, reminiscent of Hürthle cell metaplasia.
X